PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma

@article{Rodriguez2010PI3KAKTPA,
  title={PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma},
  author={Erika F. Rodriguez and Bernd Walter Scheithauer and Caterina Giannini and Amanda L Rynearson and Ling Cen and Bridget Hoesley and Heather Gilmer-Flynn and Jann N. Sarkaria and Sarah Jenkins and Jin Long and Fausto J Rodriguez},
  journal={Acta Neuropathologica},
  year={2010},
  volume={121},
  pages={407-420}
}
Pilocytic astrocytomas (PA) are well-differentiated gliomas having a favorable prognosis when compared with other diffuse or infiltrative astrocytomas. Molecular genetic abnormalities and activation of signaling pathways associated with clinically aggressive PA and histologically anaplastic PA have not been adequately studied. We performed molecular genetic, gene expression, and immunohistochemical studies using three PA subsets, including conventional PA (n = 43), clinically aggressive… CONTINUE READING