PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis

  title={PI3K/AKT activation induces PTEN ubiquitination and destabilization accelerating tumourigenesis},
  author={Min-sik Lee and Man-Hyung Jeong and Hyun-Woo Lee and Hyun-Ji Han and Aram Ko and Stephen M. Hewitt and Jae-Hoon Kim and K. W. Chun and J K Chung and Cheolju Lee and Hanbyoul Cho and Jaewhan Song},
  booktitle={Nature communications},
The activity of the phosphatase and tensin homologue (PTEN) is known to be suppressed via post-translational modification. However, the mechanism and physiological significance by which post-translational modifications lead to PTEN suppression remain unclear. Here we demonstrate that PTEN destabilization is induced by EGFR- or oncogenic PI3K mutation-mediated AKT activation in cervical cancer. EGFR/PI3K/AKT-mediated ubiquitination and degradation of PTEN are dependent on the MKRN1 E3 ligase… CONTINUE READING
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