PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning.

@article{Mocanu2002PI3KA,
  title={PI3 kinase and not p42/p44 appears to be implicated in the protection conferred by ischemic preconditioning.},
  author={Mihaela M. Mocanu and Robert M. Bell and Derek M Yellon},
  journal={Journal of molecular and cellular cardiology},
  year={2002},
  volume={34 6},
  pages={
          661-8
        }
}
Ischemic preconditioning results in an immediate phase of protection against lethal ischemia/reperfusion injury that is comprised of both irreversible necrosis and programmed cell death, apoptosis. We hypothesized that preconditioning may activate putative anti-apoptotic pathways, through the induction of either phosphatidyl inositol 3-OH kinase (PI3 kinase) or p42/p44 extracellular receptor kinase, attenuating total cell death. Isolated perfused rat hearts were preconditioned with two cycles… CONTINUE READING
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