PI3-kinase/p38 kinase-dependent E2F1 activation is critical for Pin1 induction in tamoxifen-resistant breast cancer cells.

@article{Lee2011PI3kinasep38KE,
  title={PI3-kinase/p38 kinase-dependent E2F1 activation is critical for Pin1 induction in tamoxifen-resistant breast cancer cells.},
  author={Kwang Youl Lee and Jeong Woon Lee and Hyun Nam and Jeong-Hyun Shim and Youngsup Song and Keon Wook Kang},
  journal={Molecules and cells},
  year={2011},
  volume={32 1},
  pages={107-11}
}
Acquired resistance to tamoxifen (TAM) is a serious therapeutic problem in breast cancer patients. We have shown that Pin1, a peptidyl prolyl isomerase, is consistently overexpressed in TAM-resistant MCF-7 cells (TAMR-MCF-7 cells) and plays a key role in the enhanced angiogenic potential of TAMR-MCF-7 cells. In the present study, we focused on signaling pathways for Pin1 up-regulation in TAMR-MCF-7 cells. Relative to MCF-7 cells, Pin1 gene transcription and E2 transcription factor1 (E2F1… CONTINUE READING
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