PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation

@article{Yang2001PI3KA,
  title={PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation},
  author={Feng Yang and Xiang-ping He and Linyin Feng and Keiko Mizuno and Xu-wen Liu and James Earl Russell and Wen-Cheng Xiong and B. F. Lu},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={19-28}
}
Signaling mechanisms underlying neurotrophic regulation of synaptic transmission are not fully understood. Here we show that neurotrophin-3 (NT3)-induced potentiation of synaptic transmission at the neuromuscular synapses is blocked by inhibition of phosphoinositide-3 kinase, phospholipase C-γ or the downstream IP3 receptors of phospholipase C-γ, but not by inhibition of MAP kinase. However, neither stimulation of Ca2+ release from intracellular stores by photolysis of caged IP3, nor expression… CONTINUE READING
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