PI 3 K Links NKG 2 D Signaling to a CrkL Pathway Involved in Natural Killer Cell Adhesion , Polarity , and Granule Secretion 1

The NK cell-activating receptor NKG2D plays a critical role in the destruction of malignant cells, but many of the cell-signaling mechanisms governing NKG2D-mediated cellular cytotoxicity are unknown. We have identified an NKG2D-mediated signaling pathway that governs both conjugate formation and cytotoxic granule polarization. We demonstrate that an… (More)