PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins

@article{Giordano2013PI45P2DependentAC,
  title={PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins},
  author={Francesca Giordano and Yasunori Saheki and Olof Idevall-Hagren and Sara Francesca Colombo and Michelle Pirruccello and Ira Milosevic and Elena O. Gracheva and Sviatoslav N Bagriantsev and Nica Borgese and Pietro De Camilli},
  journal={Cell},
  year={2013},
  volume={153},
  pages={1494-1509}
}
Most available information on endoplasmic reticulum (ER)-plasma membrane (PM) contacts in cells of higher eukaryotes concerns proteins implicated in the regulation of Ca(2+) entry. However, growing evidence suggests that such contacts play more general roles in cell physiology, pointing to the existence of additionally ubiquitously expressed ER-PM tethers. Here, we show that the three extended synaptotagmins (E-Syts) are ER proteins that participate in such tethering function via C2 domain… CONTINUE READING
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