• Corpus ID: 10848297

PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.

  title={PI(3)Kgamma has an important context-dependent role in neutrophil chemokinesis.},
  author={G. John Ferguson and Laura Milne and Suhasini Kulkarni and Takehiko Sasaki and Simon A Walker and Simon R. Andrews and Tom Crabbe and Peter M. Finan and Gareth E. Jones and Shaun P. Jackson and Montserrat Camps and Christian Rommel and Matthias P. Wymann and Emilio Hirsch and Phillip T. Hawkins and Len R. Stephens},
  journal={Nature cell biology},
  volume={9 1},
The directional movement of cells in a gradient of external stimulus is termed chemotaxis and is important in many aspects of development and differentiated cell function. Phophoinositide 3-kinases (PI(3)Ks) are thought to have critical roles within the gradient-sensing machinery of a variety of highly motile cells, such as mammalian phagocytes, allowing these cells to respond quickly and efficiently to shallow gradients of soluble stimuli. Our analysis of mammalian neutrophil migration towards… 
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