PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes.

@article{Ebner2017PI345P3ER,
  title={PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes.},
  author={Michael Ebner and Iva Lucic and Thomas A. Leonard and Ivan Yudushkin},
  journal={Molecular cell},
  year={2017},
  volume={65 3},
  pages={
          416-431.e6
        }
}
Protein kinase B/Akt regulates cellular metabolism, survival, and proliferation in response to hormones and growth factors. Hyperactivation of Akt is frequently observed in cancer, while Akt inactivation is associated with severe diabetes. Here, we investigated the molecular and cellular mechanisms that maintain Akt activity proportional to the activating stimulus. We show that binding of phosphatidylinositol-3,4,5-trisphosphate (PIP3) or PI(3,4)P2 to the PH domain allosterically activates Akt… CONTINUE READING
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Conformational sampling of membranes by Akt controls its activation and inactivation

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