PI(5)P Regulates Autophagosome Biogenesis

@inproceedings{Vicinanza2015PI5PRA,
  title={PI(5)P Regulates Autophagosome Biogenesis},
  author={Mariella Vicinanza and Viktor I. Korolchuk and Avraham Ashkenazi and Claudia Puri and Fiona Mhairi Menzies and Jonathan H Clarke and David C Rubinsztein},
  booktitle={Molecular cell},
  year={2015}
}
Phosphatidylinositol 3-phosphate (PI(3)P), the product of class III PI3K VPS34, recruits specific autophagic effectors, like WIPI2, during the initial steps of autophagosome biogenesis and thereby regulates canonical autophagy. However, mammalian cells can produce autophagosomes through enigmatic noncanonical VPS34-independent pathways. Here we show that PI(5)P can regulate autophagy via PI(3)P effectors and thereby identify a mechanistic explanation for forms of noncanonical autophagy. PI(5)P… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 6 times. VIEW TWEETS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

High mobility group A1 protein modulates autophagy in cancer cells

Cell Death and Differentiation • 2017
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 63 references

IIgamma in kidney to a membrane trafficking compartment within specialized cells of the nephron

H. C. Dooley, M. Razi, +3 authors S. A. Tooze
Am J Physiol Renal Physiol 295, • 2014
View 4 Excerpts
Highly Influenced

PtdIns5P: news and views of its appearance, disappearance and deeds.

Archives of biochemistry and biophysics • 2013
View 4 Excerpts
Highly Influenced

In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

Proceedings of the National Academy of Sciences of the United States of America • 2012
View 4 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…