PI(3)P-independent and -dependent pathways function together in a vacuolar translocation sequence to target malarial proteins to the host erythrocyte.

@article{Bhattacharjee2012PI3PindependentA,
  title={PI(3)P-independent and -dependent pathways function together in a vacuolar translocation sequence to target malarial proteins to the host erythrocyte.},
  author={Souvik Bhattacharjee and Kaye D. Speicher and Robert V. Stahelin and David W. Speicher and Kasturi Haldar},
  journal={Molecular and biochemical parasitology},
  year={2012},
  volume={185 2},
  pages={106-13}
}
Malaria parasites export 'a secretome' of hundreds of proteins, including major virulence determinants, from their endoplasmic reticulum (ER), past the parasite plasma and vacuolar membranes to the host erythrocyte. The export mechanism is high affinity (nanomolar) binding of a host (cell) targeting (HT) motif RxLxE/D/Q to the lipid phosphatidylinositol 3-phosphate (PI(3)P) in the ER. Cleavage of the HT motif releases the secretory protein from the ER membrane. The HT motif is thought to be the… CONTINUE READING
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