PHYSIOLOGICAL EFFECTS OF D2O IN MAMMALS *

@article{Thomson1960PHYSIOLOGICALEO,
  title={PHYSIOLOGICAL EFFECTS OF D2O IN MAMMALS *},
  author={John F. Thomson},
  journal={Annals of the New York Academy of Sciences},
  year={1960},
  volume={84}
}
  • J. F. Thomson
  • Published 1 November 1960
  • Chemistry
  • Annals of the New York Academy of Sciences
Within a few months after the announcement of the discovery of deuterium, a large number of investigators began to study the biological effects of heavy water. However, because of the scarcity and high cost of DzO, relatively little work was carried out on mammals. The most extensive systematic investigation of the pharmacology and toxicology of DzO in mice was reported by Barbour and his co-workers, beginning in 1935; the significant findings were summarized by Barbour in 1937.' Although… 
DEUTERIUM DEPLETED WATER EFFECTS ON WALKER TUMOURS
The usual concentration of deuterium in water is a bout 144 ppm D/(D+H). It is known that the increase of deuterium in the body of living animals is a naturally bioaccumulation process and could b e
THE INFLUENCE OF DEUTERIUM DEPLETED WATER ON THE HEMATOCRIT AND THE LEUKOCYTE FORMULA IN RATS INTOXICATED BY CADMIUM CHLORIDE
The present study shows the influence of the deuterium-depleted water (DDW) as compared to the drinking water on the haematocrit and the leukocyte formula on the cadmium chloride intoxication in rats
Effects of prolonged moderate body deuteration on proliferative activity in major cell renewal systems in mice.
TLDR
Drinking water containing 30 % of heavy water did not result in generalized, profound and more progressive disturbance of HTdR incorporation in all the major cell renewal systems in the mouse, and the toxicity of 30 % heavy water appears minor.
Biologic effects of orally administered deuterium oxide on rat liver.
TLDR
Lipids, nucleic acids and proteins, estimated biochemically, gradually decreased throughout the experimental period in response to D2O feeding, whereas the liver showed marginal increase in weight throughout the Experimental period.
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Enhancement by D2O of glucose‐induced cyclic AMP accumulation in rat islets of langerhans
TLDR
Using a prelabeling method for assessing changes in cyclic AMP metabolism, it is shown here that DzO, in addition to its well established inhibitory effect on insulin release, suppresses the efflux of cyclic nucleotide from the islets and the glucose-induced intra-islet accumulation of cycling AMP is greatly enhanced.
Deuterium isotope effects on lymphoid tissues and humoral antibody responses in mice
TLDR
Hematological and other morphological changes following body deuteration were evaluated in young adult pathogen-free female Swiss albino mice given heavy water as drinking fluid and the effects of reduced levels of deuterisation on antibody production and thymic morphology were evaluated.
Metabolism of Amino Acids and Organic Acids
Investigations into the metabolism of amino acids and their organic acid catabolites can be seen to have followed a few new and old paths during the interval covered by this chapter. Whereas the
Isotopic Composition of Water in Research into Phenomenon of Longevity in Mountainous and Field Areas of Bulgaria
TLDR
It was shown, that the increased content of deuterium leads to physiological, morphological and cytology alterations of the cell, and also renders negative influence on cellular metabolism, whiledeuterium depleted water with decreased deuterum content on 20-30% has beneficial effects on health.
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References

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Some effects of D2O in vivo and in vitro on certain enzymes of rat tissues
Abstract In animals that had drunk 50% heavy water until about one-third of their body water was replaced by D 2 O, changes were observed in the tissue levels of several enzymes. The arginase and
Some observations on the mechanism of toxic action of ricin.
  • J. F. Thomson
  • Chemistry, Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1950
TLDR
It is suggested that the toxic action of ricin under the conditions employed in these experiments may be explained by an interference with some metabolic process in the liver, possibly in the Krebs cycle.
The Basis of the Pharmacological Action of Heavy Water in Mammals *
  • H. Barbour
  • Computer Science, Medicine
    The Yale journal of biology and medicine
  • 1937
TLDR
Among all isotopes those which would be expected to show the greatest differences from the original element are the isotopes of hydrogen, for here the extra proton practically doubles the mass.
On the nature of the interdependence of the adrenal cortex, nonspecific stress and nutrition in the regulation of nitrogen metabolism.
  • F. Engel
  • Biology, Medicine
    Endocrinology
  • 1952
TLDR
Earlier studies led to the concept which is still widely held that certain of the metabolic alterations after injury in the healthy organism are a direct consequence of hypersecretion of adrenal cortical steroids, but later work has cast doubt on such a simple causal relationship.
Effect of D20 in vivo and in vitro on uptake of p-aminohippurate by rat kidney slices.
Kidney slices from rats in which one-third of the body water was replaced by D2O showed no impairment of the capacity to accumulate PAH, despite the moribund condition of the animals. In vitro , 100%
Effect of Adrenalectomy on Tryptophan Peroxidase, Adenosine Deaminase, And Arginase Content of Regenerating Rat Liver.∗
  • J. F. Thomson, E. M. Moss
  • Chemistry, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1955
TLDR
The concentration of tryptophan peroxidase in the livers of rats remained approximately normal one day after partial hepatectomy, and then decreased to half the control level on the second day, an indication that in non-adrenalectomized rats the high activity on the first day was attributable to an adrenal adaptive or compensatory response.
Effects of x-irradiation, nitrogen mustard, fasting, cortisone and adrenalectomy on transaminase activity in the rat.
  • M. Brin, R. McKEE
  • Biology, Medicine
    Archives of biochemistry and biophysics
  • 1956
Abstract The enhanced transaminase activities in rat liver resulting from x-irradiation, nitrogen mustard, and starvation, and in intestine resulting from starvation are probably secondary to the
Studies on the enzymic dehydrogenation of deuterated succinate.
TLDR
Increase the deuterium content of succinic acid decreased the rate of dehydrogenation by succinoxidase, and metabolism of succinate by liver slices showed the same effect of deuteration of the substrate that was observed with cell-free preparations, except that the isotope effect was somewhat less.
Changes in Renal Function in Rats Drinking Heavy Water.∗
  • J. F. Thomson, F. J. Klipfel
  • Chemistry, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1958
Summary Glomerular filtration and renal plasma flow were decreased to about 40% of normal in rats drinking 50 mole % D2O. Upon transfer from D2O to H2O, renal function rapidly returned to normal. It
Failure of Growth in Disturbed Laboratory Rats
TLDR
Rats which were exposed to disturbances either lost weight or they failed to gain it as quickly as undisturbed controls, and this measure has previously been found a particularly useful measure.
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