• Corpus ID: 66215


  author={Sanjay S. Jain and Champalal Dhanotiya and Neelesh Kumar Malviya},
Rutin belongs to a class of plant secondary metabolites called flavonoids. Rutin is believed to be a vital nourishing supplement as it is able to make the capillaries stronger. But when administered orally it shows poor absorption because of less lipophilicity. To overcome this limitation, the present study was aimed to develop Rutinphospholipid complex in different ratio to improve the lipophilic properties of rutin. The prepared complex was evaluated for physicochemical properties and in… 

Figures from this paper

Design and Evaluation of Phyto-Phospholipid Complexes (Phytosomes) of Rutin for Transdermal Application

The observations made in the present work suggest that phyto-phospholipid complex of Rutin can increase its skin uptake to treat inflammatory conditions in arthritis, rheumatism, athletic aches and may able to deliver the drug for a long duration avoiding the problems associated with oral administration.

Preparation and Evaluation of Curcumin Phytosomes

Curcumin, a hydrophobic polyphenol derived from the rhizome of Curcuma longa L. (Zingiberaceae or dietary Curcumin) has been shown to exhibit antioxidant, anti-inflammatory, antimicrobial,

Fluorescence and Ultraviolet Spectroscopic Evaluation of Phenolic Compounds, Antioxidant and Binding Activities in Some Kiwi Fruit Cultivars

Spectrophotometric assays (Folin–Ciocalteu, ferric-reducing/antioxidant power, cupric-reducing antioxidant capacity, and β-carotene linoleate model system) have been used to evaluate the total

Effect of high-pressure homogenization on formulation of TPGS loaded nanoemulsion of rutin – pharmacodynamic and antioxidant studies

It can be inferred that TPGS-loaded nanoemulsion of RU serve as an effective tool in increasing solubility and permeability of RU.

Phyto-Phospholipid Complexes as Drug Delivery System for Herbal Extracts/Molecules

In this review, introducing the most important points in phytosome and canalizing the researchers to this drug delivery system designed for herbal extracts/molecules are aimed.

Formulation and Stability Characterization of Rutin-Loaded Oil-in-Water Emulsions

In this work, formulation and characterization of oil-in-water (O/W) emulsions loaded with rutin were successfully overhead. We investigated the effect of homogenization pressure on the mean droplet

Critical Review of Lipid-Based Nanoparticles as Carriers of Neuroprotective Drugs and Extracts

This review summarizes current research on lipid-based nanoparticles for the nanoencapsulation of neuroprotective compounds and discusses the transport mechanisms through which compounds or nanoparticles may cross BBB into the brain parenchyma, and the potential to increase drug bioavailability.

Electroformation of liposomes and phytosomes using copper electrode

The method was successfully applied to prepare phytosomes from egg-PC and a phytochemical fraction of Dimorphocalyx glabellus, a medicinal plant with anti-diuretic properties that will prove to be useful for preparation of liposomes and phytOSomes.

Phytosome Drug Delivery of Natural Products: A Promising Technique for Enhancing Bioavailability

The phytosome technology was developed by Indena markedly enhancing the bioavailability of selected phytomedicines, by incorporating phospholipids into standardized plant extract, which improve their



Physicochemical Properties and Antioxidant Activities of Luteolin-Phospholipid Complex

It was found that the luteolin and phospholipid complex was an effective scavenger of DPPH radicals, with an IC50 value of 28.33 μg/mL, and showed the strong antioxidant activity in the Rancimat antioxidant test.

In vitro antioxidant studies of Sphaeranthus indicus (Linn).

The results justify the therapeutic applications of the plant in the indigenous system of medicine, augmenting its therapeutic value, and total antioxidant capacity of the extract was found to be 160.85 nmol/g ascorbic acid.

Antioxidant Activity of Stem Bark of Thespesia populnea Soland ex Corr.

Objective: To evaluate the antioxidant activity of stem bark of Thespesia populnea . Materials and Method: Antioxidant activity of T. populnea stem bark was studied in four in vitro / ex vivo models,

Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans

The disposition of quercetin in humans primarily depends on the sugar moiety, and to a minor extent, the plant matrix influences both the rate and extent of absorption in the case of buckwheat tea administration compared with the isolated compound.

Biodegradable nanoparticles containing protein-fatty acid complexes for oral delivery of salmon calcitonin.

It is shown that physical complexation of sCT with amphiphilic molecules enabled the formation of s CT-loaded PLGA nanoparticles at a high loading efficiency and that sCT-PLGA nanoparticle were transported across the Caco-2 cell monolayer and were readily taken up in vivo following oral admistration.

Practical aspects of lyophilization using non-aqueous co-solvent systems.

  • D. TeagardenDavid S. Baker
  • Chemistry
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2002