PHRs: bridging axon guidance, outgrowth and synapse development.

@article{Po2010PHRsBA,
  title={PHRs: bridging axon guidance, outgrowth and synapse development.},
  author={Michelle D. Po and Christine Hwang and Mei Zhen},
  journal={Current opinion in neurobiology},
  year={2010},
  volume={20 1},
  pages={100-7}
}
Axon guidance, outgrowth, and synapse formation are interrelated developmental events during the maturation of the nervous system. Establishing proper synaptic connectivity requires precise axon navigation and a coordinated switch between axon outgrowth and synaptogenesis. The PHR (human Pam, mouse Phr1, zebrafish Esrom, DrosophilaHighwire, and C. elegansRPM-1) protein family regulates both axon and synapse development through their biochemical and functional interactions with multiple… CONTINUE READING
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