PHRs: bridging axon guidance, outgrowth and synapse development

  title={PHRs: bridging axon guidance, outgrowth and synapse development},
  author={Michelle D. Po and C. Hwang and M. Zhen},
  journal={Current Opinion in Neurobiology},
  • Michelle D. Po, C. Hwang, M. Zhen
  • Published 2010
  • Biology, Medicine
  • Current Opinion in Neurobiology
  • Axon guidance, outgrowth, and synapse formation are interrelated developmental events during the maturation of the nervous system. Establishing proper synaptic connectivity requires precise axon navigation and a coordinated switch between axon outgrowth and synaptogenesis. The PHR (human Pam, mouse Phr1, zebrafish Esrom, DrosophilaHighwire, and C. elegansRPM-1) protein family regulates both axon and synapse development through their biochemical and functional interactions with multiple… CONTINUE READING
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