PHR regulates growth cone pausing at intermediate targets through microtubule disassembly.

@article{Hendricks2009PHRRG,
  title={PHR regulates growth cone pausing at intermediate targets through microtubule disassembly.},
  author={Michael Hendricks and Suresh Jesuthasan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2009},
  volume={29 20},
  pages={
          6593-8
        }
}
Axonal growth cones use intermediate targets to navigate in the developing nervous system. Encountering these sites is correlated with growth cone pausing. PHR (Phr1, Esrom, Highwire, RPM-1) is a large neuronal ubiquitin ligase that interacts with multiple signaling pathways. Mouse and zebrafish phr mutants have highly penetrant axon pathfinding defects at intermediate targets. Mouse phr mutants contain excessive microtubules in the growth cone, which has been attributed to upregulation of DLK… CONTINUE READING
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