PHOTOSENSITIZATION BY PORPHYRINS DELIVERED TO L CELL FIBROBLASTS BY HUMAN SERUM LOW DENSITY LIPOPROTEINS. A MICROSPECTROFLUOROMETRIC STUDY

@article{Morlire1987PHOTOSENSITIZATIONBP,
  title={PHOTOSENSITIZATION BY PORPHYRINS DELIVERED TO L CELL FIBROBLASTS BY HUMAN SERUM LOW DENSITY LIPOPROTEINS. A MICROSPECTROFLUOROMETRIC STUDY},
  author={P. Morli{\'e}re and E. Kohen and J. P. Reyftmann and R. Santus and C. Kohen and J. Mazi{\`e}re and S. Goldstein and W. Mangel and L. Dubertret},
  journal={Photochemistry and Photobiology},
  year={1987},
  volume={46}
}
  • P. Morliére, E. Kohen, +6 authors L. Dubertret
  • Published 1987
  • Chemistry, Medicine
  • Photochemistry and Photobiology
    • Human serum LDL were used as vehicles to deliver protoporphyrin and hematoporphyrin dimer to L cell mouse fibroblasts. Topographic analysis by microspectrofluorometry on single living cells shows that after digestion of LDL, protoporphyrin is localized in cytoplasmic areas. Protoporphyrin and hematoporphyrin dimer are readily bleached by 420 ± 60 nm radiations at the high fluence rate used. Complex bleaching kinetics are observed. Spectral studies using the same technique demonstrate that an… CONTINUE READING
    View on Wiley
    ncbi.nlm.nih.gov
    49 Citations
    Background Citations
    1
    49 Citations
    Citation Type

    Citation Type

    Lysosomes Are Sites of Fluoroquinolone Photosensitization in Human Skin Fibroblasts: A Microspectrofluorometric Approach*
    • 59
    SUBCELLULAR LOCALIZATION OF AND PHOTOSENSITIZATION BY PROTOPORPHYRIN IX IN HUMAN KERATINOCYTES AND FIBROBLASTS CULTIVATED WITH 5‐AMINOLEVULINIC ACID
    • 61
    PHOTOSENSITIZATION BY PHOTOFRIN II DELIVERED TO WI26VA4 SV40‐TRANSFORMED HUMAN FIBROBLASTS BY LOW DENSITY LIPOPROTEINS: INHIBITION OF LIPID SYNTHESIS AND FATTY ACID UPTAKE
    • 15
    Damage to mitochondria of cultured human skin fibroblasts photosensitized by fluoroquinolones.
    • 41
    Photochemical treatment with the lysosomally localized dye tetra(4-sulfonatophenyl)porphine results in lysosomal release of the dye but not of beta-N-acetyl-D-glucosaminidase activity.
    • 27
    In vivo transport and pharmacokinetic behavior of tumour photosensitizers.
    • G. Jori
    • Chemistry, Medicine
    • Ciba Foundation symposium
    • 1989
    • 89
    Alteration of the Endocytotic Pathway by Photosensitization with Fluoroquinolones ¶
    Alteration of the Endocytotic Pathway by Photosensitization with Fluoroquinolones¶
    • 16
    Photosensitization of Wi26-VA4 transformed human fibroblasts by low density lipoprotein loaded with the anticancer porphyrin mixture photofrin II: evidence for endoplasmic reticulum alteration.
    • 32
    Lysosomes, a key target of hydrophobic photosensitizers proposed for photochemotherapeutic applications.
    • 83

    References

    SHOWING 1-10 OF 48 REFERENCES
    In vitro interaction of the photoactive anticancer porphyrin derivative photofrin II with low density lipoprotein, and its delivery to cultured human fibroblasts
    • 83
    Targeted killing of cultured cells by receptor-dependent photosensitization.
    • 62
    • PDF
    Transport and binding of hematoporphyrin derivative and related porphyrins by murine leukemia L1210 cells.
    • D. Kessel
    • Chemistry, Medicine
    • Cancer research
    • 1981
    • 101
    • PDF
    A MICROSPECTROFLUOROMETRIC STUDY OF PORPHYRIN‐PHOTOSENSITIZED SINGLE LIVING CELLS— I. MEMBRANE ALTERATIONS
    • 38
    PERMEATION OF LYSOSOMAL MEMBRANES IN THE COURSE OF PHOTOSENSITIZATION WITH METHYLENE BLUE AND HEMATOPORPHYRIN: STUDY BY CELLULAR MICROSPECTROFLUOROMETRY
    • 79
    Microspectrofluorometry of fluorescent photoproducts in photosensitized cells. Relationship to cellular quiescence and senescence in culture.
    • 15
    Monensin interrupts the recycling of low density lipoprotein receptors in human fibroblasts
    • 498
    Binding and degradation of low density lipoproteins by cultured human fibroblasts. Comparison of cells from a normal subject and from a patient with homozygous familial hypercholesterolemia.
    • 1,183
    • PDF
    Porphyrin-induced photodamage as related to the subcellular localization of the porphyrins.
    • 42
    Lipoproteins as potential site-specific delivery systems for diagnostic and therapeutic agents.
    • 84