PHOTOSENSITIZATION BY PORPHYRINS DELIVERED TO L CELL FIBROBLASTS BY HUMAN SERUM LOW DENSITY LIPOPROTEINS. A MICROSPECTROFLUOROMETRIC STUDY

@article{Morlire1987PHOTOSENSITIZATIONBP,
  title={PHOTOSENSITIZATION BY PORPHYRINS DELIVERED TO L CELL FIBROBLASTS BY HUMAN SERUM LOW DENSITY LIPOPROTEINS. A MICROSPECTROFLUOROMETRIC STUDY},
  author={P. Morli{\'e}re and E. Kohen and J. P. Reyftmann and R. Santus and C. Kohen and J. Mazi{\`e}re and S. Goldstein and W. Mangel and L. Dubertret},
  journal={Photochemistry and Photobiology},
  year={1987},
  volume={46}
}
  • P. Morliére, E. Kohen, +6 authors L. Dubertret
  • Published 1987
  • Chemistry, Medicine
  • Photochemistry and Photobiology
  • Human serum LDL were used as vehicles to deliver protoporphyrin and hematoporphyrin dimer to L cell mouse fibroblasts. Topographic analysis by microspectrofluorometry on single living cells shows that after digestion of LDL, protoporphyrin is localized in cytoplasmic areas. Protoporphyrin and hematoporphyrin dimer are readily bleached by 420 ± 60 nm radiations at the high fluence rate used. Complex bleaching kinetics are observed. Spectral studies using the same technique demonstrate that an… CONTINUE READING
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