PHOTOFRIN‐mediated photodynamic therapy for treatment of early stage (Tis‐T2N0M0) SqCCa of oral cavity and oropharynx

  title={PHOTOFRIN‐mediated photodynamic therapy for treatment of early stage (Tis‐T2N0M0) SqCCa of oral cavity and oropharynx},
  author={Vanessa Gayl Schweitzer and Melissa L. Somers},
  journal={Lasers in Surgery and Medicine},
To evaluate the efficacy of dihematoporphyrin ether (PHOTOFRIN)‐mediated photodynamic therapy (PDT) for the treatment of diffuse field cancerization and Tis‐T2N0M0 squamous cell carcinoma (SqCCA) of the oral cavity and oropharynx in patients not amenable to or that have failed conventional head and neck cancer treatment. 

Photodynamic therapy: the imminent milieu for treating oral lesions.

Oral infections (such as mucosal and endodontic infections, periodontal diseases, caries, and peri-implantitis) are among the specific targets where PDT can be applied, and efficacy depends on the local dose deposited in the lesion as well as oxygen availability in theLesion.

Photodynamic Therapy of Oral Cavity Tumors in Low Resource Settings: Technology Development, Feasibility and Evaluation in Patients

A light-based therapy namely Photodynamic therapy (PDT) is presented that showed promise, specifically excellent mucosal healing, in treatment of oral cancers and other malignancies and is presented as a low-cost modality.

Photodynamic therapy: The minimally invasive surgical intervention for advanced and/or recurrent tongue base carcinoma

Patients' reports on quality of life with clinical and radiological evaluation were the main end point parameters used to assess the outcome following ultrasound‐guided interstitial photodynamic therapy of stage IV tongue base cancer patients.

Photodynamic therapy in the upper aerodigestive tract. Overview and outlook

A contemporary and comprehensive review on the role of photodynamic therapy in the treatment of (pre)malignancies of the UADT is presented and further clinical studies are needed to better define its true value in head and neck oncology.

Photodynamic therapy for head and neck lesions in the subtropics.

  • F. Civantos
  • Medicine
    Journal of the National Comprehensive Cancer Network : JNCCN
  • 2012
A current perspective is offered from a fairly selective PDT program that has achieved dramatic lasting responses and where PDT may fit in the treatment spectrum for head and neck cancers is one of the unanswered questions requiring further study.

Oral Cavity: Early Lesions

Possible sensitizers are discussed that can be employed to treat early squamous cell carcinomas of the oral cavity that can provide the possibility of reducing side effects.

Photodynamic therapy for squamous cell carcinoma of the head and neck: narrative review focusing on photosensitizers

It is suggested that PDT is a promising treatment modality for early-stage SCCHN, and the low level of evidence of the included studies could help to design robust clinical trials to determine the efficacy of PDT inSCCHN.

The Efficacy of Photodynamic Therapy in the Treatment of Oral Squamous Cell Carcinoma: A Meta-Analysis

It is concluded that PDT is as effective as primary surgical resection for the treatment of early-stage SCC of the oral cavity and that it is a valid function-preserving approach to treatment.

Photodynamic Therapy (PDT): An Evolving Therapeutic Technique in Head and Neck Cancer Treatment

This chapter serves to provide a general background of the PDT technique and discusses how PDT is currently used clinically to treat head and neck cancers, as well as for aesthetic and cosmetic purposes.



PHOTOFRIN‐mediated photodynamic therapy for treatment of early stage oral cavity and laryngeal malignancies *

To determine the efficacy of PHOTOFRIN‐mediated photodynamic therapy (PDT) for treatment of diffuse “field cancerization” of the oral cavity and Cis‐T2N0M0 squamous cell carcinoma (SqCCa) of the

Photodynamic therapy using 5‐aminolevulinic acid for premalignant and malignant lesions of the oral cavity

The use of PDT with the photosensitizing agent 5‐aminolevulinic acid (ALA) for premalignant and malignant lesions of the mouth is described.

Photodynamic Therapy Treatment of Early Oral and Laryngeal Cancers †

  • M. Biel
  • Medicine
    Photochemistry and photobiology
  • 2007
Photodynamic therapy has been successfully employed to treat early carcinomas of the oral cavity and larynx preserving normal tissue and vital functions of speech and swallowing.

Photodynamic therapy in the treatment of multiple primary tumours in the head and neck, located to the oral cavity and oropharynx

This study aims at evaluating meta‐tetrahydroxy‐phenyl chlorin‐mediated photodynamic therapy for second or multiple primary tumours in the head and neck.

Meta-tetra(hydroxyphenyl)chlorin photodynamic therapy in early-stage squamous cell carcinoma of the head and neck.

This study confirms that PDT is a powerful treatment modality that could be considered as an alternative to surgery or radiotherapy in specific cases of head and neck cancer, and reduces the reduction in long-term morbidity.

mTHPC‐mediated photodynamic therapy for early oral squamous cell carcinoma

An open‐label, multicentre study to assess the efficacy and safety of meta‐tetrahydroxyphenylchlorin (mTHPC) in patients with early oral cancer concluded that mTHPC offers an effective alternative treatment for early oral squamous cell carcinoma.

Methyl aminolevulinate-PDT for actinic keratoses and superficial nonmelanoma skin cancers.

Current evidence has shown that this noninvasive treatment is superior in terms of cosmetic outcome to other management strategies such as surgery, and offers the advantages of relative simplicity, low risk of side-effects and decreased complications due to scar formation.

Photodynamic therapy/Oncology

The current use of first- and second-generation photosensitisers in oncology is reviewed, especially absorption of longer wavelength light which penetrates deeper into tissue and faster clearance from normal tissue.

Prognostic factors in the recurrence of stage I and II squamous cell cancer of the oral cavity.

It is revealed that when various interactions between variables were controlled for, only the presence of a positive surgical margin or a tumor depth greater than 5 mm was significantly associated with recurrence, and each individually increased the likelihood of recurrence almost threefold.

Topical application of photofrin for photodynamic diagnosis of oral neoplasms.

Light-induced fluorescence detection using topical Photofrin provides a sensitive, noninvasive technique for the early identification of malignant neoplasms in the oral cavity.