PHOSPHATIDYLINOSITOL METABOLISM IN RAT BRAIN PREPARATIONS

@inproceedings{Strickland1978PHOSPHATIDYLINOSITOLMI,
  title={PHOSPHATIDYLINOSITOL METABOLISM IN RAT BRAIN PREPARATIONS},
  author={Kenneth P. Strickland and Patrick Shum and Raghav Rao},
  year={1978}
}
SUMMARY: Brief review is made of the data which show that the de novo synthesis of phosphatidylinositol (PI) in rat brain occurs in the endoplasmic reticulum (in vitro the microsomal fraction) by a pathway involving the formation of phosphatidic acid (PA) and CDP-diacylglycerol (CDP-diglyceride) as intermediates. A potential regulatory role by the cytosine nucleotides is commented upon. The essential findings from more recent studies on the two transferase enzymes responsible for PI formation… CONTINUE READING