PHO13 deletion-induced transcriptional activation prevents sedoheptulose accumulation during xylose metabolism in engineered Saccharomyces cerevisiae.

@article{Xu2016PHO13DT,
  title={PHO13 deletion-induced transcriptional activation prevents sedoheptulose accumulation during xylose metabolism in engineered Saccharomyces cerevisiae.},
  author={Haiqing Xu and Sooah Kim and Hagit Sorek and Youngsuk Lee and Deokyeol Jeong and Jungyeon Kim and Eun Joong Oh and Eun Ju Yun and David E Wemmer and Kyoung Heon Kim and Soo Rin Kim and Yong-Su Jin},
  journal={Metabolic engineering},
  year={2016},
  volume={34},
  pages={88-96}
}
The deletion of PHO13 (pho13Δ) in Saccharomyces cerevisiae, encoding a phosphatase enzyme of unknown specificity, results in the transcriptional activation of genes related to the pentose phosphate pathway (PPP) such as TAL1 encoding transaldolase. It has been also reported that the pho13Δ mutant of S. cerevisiae expressing a heterologous xylose pathway can metabolize xylose efficiently compared to its parental strain. However, the interaction between the pho13Δ-induced transcriptional changes… CONTINUE READING