PHLPP phosphatase: a key mediator integrating multiple signaling pathways

  • Hui Zhong
  • Published 2010 in Frontiers in Biology


Cellular responses to bacterial or viral infections and to stress require rapid and accurate transmission of signals from cell-surface receptors to the nucleus (Karin and Hunter, 1995). These signaling pathways, relying on extensive protein phosphorylation events, lead to the activation of specific transcription factors that induce the expression of… (More)
DOI: 10.1007/s11515-010-0041-6