PHF8 Mediates Histone H4 Lysine 20 Demethylation Events Involved in Cell Cycle Progression

@inproceedings{Liu2010PHF8MH,
  title={PHF8 Mediates Histone H4 Lysine 20 Demethylation Events Involved in Cell Cycle Progression},
  author={Wen Bin Liu and Bogdan Tanasa and Oksana V. Tyurina and Tian Yuan Zhou and Reto Gassmann and Wei Ting Liu and Kenneth a. Ohgi and Chris Benner and Ivan Garcia-Bassets and Aneel K. Aggarwal and Arshad B Desai and Pieter C. Dorrestein and Christopher K. Glass and Michael G. Rosenfeld},
  booktitle={Nature},
  year={2010}
}
While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for histone H4 lysine 20 and their potential regulatory roles remain unknown. Here we report that the PHD and Jumonji C (JmjC) domain-containing protein, PHF8, while using multiple substrates, including H3K9me1/2 and H3K27me2, also functions as an H4K20me1 demethylase. PHF8 is recruited to promoters by its PHD domain based on interaction with H3K4me2/3 and controls G1–S… CONTINUE READING

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