PHF8 Mediates Histone H4 Lysine 20 Demethylation Events Involved in Cell Cycle Progression

  title={PHF8 Mediates Histone H4 Lysine 20 Demethylation Events Involved in Cell Cycle Progression},
  author={W. Liu and Bogdan Tanasa and O. Tyurina and T. Y. Zhou and Reto Gassmann and K. Ohgi and Chris Benner and Ivan Garcia-Bassets and A. Aggarwal and A. Desai and P. Dorrestein and C. Glass and M. Rosenfeld},
  pages={508 - 512}
  • W. Liu, Bogdan Tanasa, +11 authors M. Rosenfeld
  • Published 2010
  • Biology, Medicine
  • Nature
  • While reversible histone modifications are linked to an ever-expanding range of biological functions, the demethylases for histone H4 lysine 20 and their potential regulatory roles remain unknown. Here we report that the PHD and Jumonji C (JmjC) domain-containing protein, PHF8, while using multiple substrates, including H3K9me1/2 and H3K27me2, also functions as an H4K20me1 demethylase. PHF8 is recruited to promoters by its PHD domain based on interaction with H3K4me2/3 and controls G1–S… CONTINUE READING
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