PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer

@article{Lee2015PHF2HD,
  title={PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer},
  author={Koo Yul Lee and Dubok Park and H-S Sung and Young Chan Choi and Woo Hyang Kim and Hun Seok Lee and H-J Chung and Hyun-Woo Shin and Chunho Cho and Tackjin Kim and S-h Li and Hee-sang Youn and Seong Jung Kim and Yoon Kwon Chun},
  journal={Oncogene},
  year={2015},
  volume={34},
  pages={2897-2909}
}
Plant homeodomain finger 2 (PHF2) has a role in epigenetic regulation of gene expression by demethylating H3K9-Me2. Several genome-wide studies have demonstrated that the chromosomal region including the PHF2 gene is often deleted in some cancers including colorectal cancer, and this finding encouraged us to investigate the tumor suppressive role of PHF2. As p53 is a critical tumor suppressor in colon cancer, we tested the possibility that PHF2 is an epigenetic regulator of p53. PHF2 was… CONTINUE READING
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