PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer

@article{Lee2014PHF2HD,
  title={PHF2 histone demethylase acts as a tumor suppressor in association with p53 in cancer},
  author={K. Lee and J. Park and H-S Sung and Y. Choi and W. Kim and H. Lee and H-J Chung and H-W Shin and C. Cho and T.-Y. Kim and S. Li and H-D Youn and S. Kim and Y. Chun},
  journal={Oncogene},
  year={2014},
  volume={34},
  pages={2897-2909}
}
  • K. Lee, J. Park, +11 authors Y. Chun
  • Published 2014
  • Biology, Medicine
  • Oncogene
  • Plant homeodomain finger 2 (PHF2) has a role in epigenetic regulation of gene expression by demethylating H3K9-Me2. Several genome-wide studies have demonstrated that the chromosomal region including the PHF2 gene is often deleted in some cancers including colorectal cancer, and this finding encouraged us to investigate the tumor suppressive role of PHF2. As p53 is a critical tumor suppressor in colon cancer, we tested the possibility that PHF2 is an epigenetic regulator of p53. PHF2 was… CONTINUE READING
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    References

    SHOWING 1-10 OF 35 REFERENCES
    Role of the Histone Acetyl Transferase Tip60 in the p53 Pathway*
    • 127
    • PDF
    Synergistic activation of transcription by CBP and p53
    • 626
    Epigenetic Regulation of Adipogenesis by PHF2 Histone Demethylase
    • 43
    • PDF
    Repression of p53 activity by Smyd2-mediated methylation
    • 493
    p53-mediated heterochromatin reorganization regulates its cell fate decisions
    • 40
    Modulation of p53 function by SET8-mediated methylation at lysine 382.
    • 355