PHF10 Is Required for Cell Proliferation in Normal and SV40-Immortalized Human Fibroblast Cells

@inproceedings{Banga2009PHF10IR,
  title={PHF10 Is Required for Cell Proliferation in Normal and SV40-Immortalized Human Fibroblast Cells},
  author={Satnam S. Banga and Liangping Peng and Tanya Dasgupta and Vaseem A Palejwala and Harvey L. Ozer},
  booktitle={Cytogenetic and genome research},
  year={2009}
}
Normal human diploid fibroblasts have limited life span in culture and undergo replicative senescence after 50-60 population doublings. On the contrary, cancer cells typically divide indefinitely and are immortal. Expression of SV40 large T and small t antigens in human fibroblasts transiently extends their life span by 20-30 population doublings and facilitates immortalization. We have identified a rearrangement in chromosome 6 shared by SV40-transformed human fibroblasts. Rearrangements… CONTINUE READING
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