PHEREXA: A phase III study of trastuzumab (H) + capecitabine (X) ± pertuzumab (P) for patients (pts) who progressed during/after one line of H-based therapy in the HER2-positive metastatic breast cancer (MBC) setting.

@inproceedings{Urruticoechea2016PHEREXAAP,
  title={PHEREXA: A phase III study of trastuzumab (H) + capecitabine (X) ± pertuzumab (P) for patients (pts) who progressed during/after one line of H-based therapy in the HER2-positive metastatic breast cancer (MBC) setting.},
  author={Ander Urruticoechea and Mohammed Rizwanullah and S. A. Im and Antonio Carlos S{\'a}nchez-Ruiz and Istv{\'a}n L{\'a}ng and Gianluca Tomasello and Hannah Douthwaite and Tanja Badovinac {\vC}rnjevi{\'c} and Sarah Heeson and Jennifer Eng-Wong and Montserrat Palma i Mu{\~n}oz},
  year={2016}
}
504Background: P provides a progression-free and overall survival (PFS, OS) benefit in HER2-positive MBC, and is standard of care in the 1st line. Continuing H post-progression on 1st-line H improves response and time to progression. H + X is well tolerated and more effective than X in these pts, and dual P + H anti-HER2 therapy has activity in this population. However, efficacy and safety of P + H + X is unknown. We report the primary analysis of a multicenter, open-label randomized study of H… CONTINUE READING

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3rd ESO-ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3).

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3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3)

  • Annals of oncology : official journal of the European Society for Medical Oncology
  • 2017
VIEW 2 EXCERPTS
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