PHENAZOCINE, A NEW BENZOMORPHAN NARCOTIC ANALGESIC

@article{Eckenhoff1959PHENAZOCINEAN,
  title={PHENAZOCINE, A NEW BENZOMORPHAN NARCOTIC ANALGESIC},
  author={JAMES E. Eckenhoff},
  journal={Anesthesiology},
  year={1959},
  volume={20},
  pages={355–358}
}
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17 Citations
Highly Influential Citations
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17 Citations

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Studies of drugs given before anaesthesia. 13. Pentazocine and other opiate antagonists.
TLDR
The non-addicting analgesic pentazocine (Fortral) was compared with the established opiate antagonists nalorphine and levallorphan when used in pre-operative medication in female patients and the antagonists were all less toxic than the addicting opiates, though all were worse than saline.
CATARACT EXTRACTION UNDER COMBINED LOCAL AND GENERAL ANALGESIA USING PHENAZOCINE*
THE recent introduction of a powerful general analgesic drug, phenazocine (" Narphen"), with a potency stated to be seven to ten times that of morphine (Eckenhoff, 1959) has enabled us to make use of…
Laboratory and clinical experience with phenazocine during anaesthesia
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Phenazocine does not possess the histamine-releasing properties associated with meperidine, but is capable of inducing a reduction of the respiratory rate in animals and in man.
ANALGESIA AND ADDICTION.
  • L. MellettL. A. Woods
  • Medicine
    Fortschritte der Arzneimittelforschung. Progress in drug research. Progres des recherches pharmaceutiques
  • 1963
TLDR
It is an unfortunate fact that the potent drugs which produce analgesia are concomitantly addicting, i.e. that they produce physical and psychic dependence as well as exhibiting the phenomenon of tolerance development.
Clinical pharmacology of potent analgesics
TLDR
The object of this review is to summarize the current knowledge of morphine and morphinelike drugs and to suggest that if used wisely, morphine, the oldest agent, is still one of the best.
2 The Testing and Development of Analgesic Drugs
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