PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.


Cellular response to hypoxia plays an important role in both circulatory and pulmonary diseases and cancer. Hypoxia-inducible factors (HIFs) are major transcription factors regulating the response to hypoxia. The α-subunits of HIFs are hydroxylated by members of the prolyl-4-hydroxylase domain (PHD) family, PHD1, PHD2, and PHD3, in an oxygen-dependent… (More)
DOI: 10.1016/j.yexcr.2011.09.005


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