PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation.

Abstract

Cellular response to hypoxia plays an important role in both circulatory and pulmonary diseases and cancer. Hypoxia-inducible factors (HIFs) are major transcription factors regulating the response to hypoxia. The α-subunits of HIFs are hydroxylated by members of the prolyl-4-hydroxylase domain (PHD) family, PHD1, PHD2, and PHD3, in an oxygen-dependent… (More)
DOI: 10.1016/j.yexcr.2011.09.005

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