PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors

@article{Deshpande2007PHC3AC,
  title={PHC3, a component of the hPRC-H complex, associates with E2F6 during G0 and is lost in osteosarcoma tumors},
  author={Amit M Deshpande and Jennifer D Akunowicz and Xavier T Reveles and Bhaven B Patel and Elizabeth A. Saria and Richard Greg Gorlick and S. L. Naylor and Robin J. Leach and Marc F. Hansen},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={1714-1722}
}
Polyhomeotic-like 3 (PHC3) is a ubiquitously expressed member of the polycomb gene family and part of the human polycomb complex hPRC-H. We found that in normal cells PHC3 associated with both hPRC-H complex components and with the transcription factor E2F6. In differentiating and confluent cells, PHC3 and E2F6 showed nuclear colocalization in a punctate pattern that resembled the binding of polycomb bodies to heterochromatin. This punctate pattern was not seen in proliferating cells suggesting… CONTINUE READING

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Tumour-suppressor genes: evolving definitions in the genomic age

Nature Genetics • 1997
View 4 Excerpts
Highly Influenced

Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY

E Harlow, D. Lane
1988
View 5 Excerpts
Highly Influenced

A gene complex controlling segmentation in Drosophila

Nature • 1978
View 4 Excerpts
Highly Influenced

BMI1 is a target gene of E2F-1 and is strongly expressed in primary neuroblastomas

K Nowak, K Kerl, +3 authors K Killmer
Nucleic Acids Res • 2006
View 1 Excerpt

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