• Corpus ID: 29145964

PHARMACOPHORE MODELING AND QSAR STUDY OF THIENO (3, 2 - b) PYRIMIDINE ANALOGS AS VEGFR-2 INHIBITORS Original Article

@inproceedings{Prabhu2014PHARMACOPHOREMA,
  title={PHARMACOPHORE MODELING AND QSAR STUDY OF THIENO (3, 2 - b) PYRIMIDINE ANALOGS AS VEGFR-2 INHIBITORS Original Article},
  author={Krishnananda Prabhu and Manoj Kumar and V. K. Gopalakrishnan},
  year={2014}
}
Objective: Vascular endothelial growth factor (VEGF) and its receptor tyrosine kinase VEGFR-2 are critical regulators for the activation of angiogenesis and tumor progression. Thus the VEGFR-2 inhibition represents an attractive target for drug discovery in most of the cancers. To know the structural requirements that will lead to enhanced inhibitory activities, the 3D-QSAR (quantitative structure-activity relationship) studies were performed on series of thieno [3, 2 - b] pyrimidine molecules… 
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