Development of 5-Substituted N-Methylmorphinan-6-ones as Potent Opioid Analgesics with Improved Side-Effect Profile
- BiologyInternational journal of medicinal chemistry
14-alkoxy-N-methylmorphinan-6-ones having a methyl and benzyl group at position 5 are reported on as strong opioid antinociceptive agents with reduced propensity to cause undesired effects compared to morphine although interacting selectively with MORs.
Study on the Activation of the Opioid Receptors by a Set of Morphine Derivatives in a Well-Defined Assay System
- Biology, ChemistryNeurochemical Research
This is the first comparative and comprehensive report on the activation of the three different opioid receptors by a set of morphine derivatives in a well-defined assay system and it is noteworthy that the 6-O-methyl group seems to improve the selectivity for κ receptor.
Kappa opioids and the modulation of pain
- Biology, MedicinePsychopharmacology
The pharmacological profile of Kop agonists in visceral pain models suggest that peripherally restricted KOP agonists are potentially useful for a variety of peripheral pain states.
Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors.
- Biology, ChemistryEuropean journal of pharmacology
N-Methyl and N-cyclopropylmethyl-14α,14′β-[dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydro-5β-methyl-morphinone) MET-TAMO and N-CPM-MET-TAMO: Synthesis and opioid binding properties
Nature of the receptor sites for galactosyl-specific lectins on human lymphocytes.
- Biology, ChemistryExperimental cell research
Clinical pharmacology of potent analgesics
The object of this review is to summarize the current knowledge of morphine and morphinelike drugs and to suggest that if used wisely, morphine, the oldest agent, is still one of the best.
A STEREOTYPED RESPONSE INDUCED BY MESCALINE IN MICE AS A MEANS OF INVESTIGATING THE PROPERTIES OF DRUGS ACTING ON THE CNS
- Psychology, BiologyThe Journal of pharmacy and pharmacology
The effects of mescaline on spontaneous activity of mice placed in special cages have been studied and the typical response has been recorded and assessed in terms of percentage of animals showing the effect.