PHARMACOLOGICAL ASPECTS OF HUMAN AND CANINE NARCOLEPSY

@article{Nishino1997PHARMACOLOGICALAO,
  title={PHARMACOLOGICAL ASPECTS OF HUMAN AND CANINE NARCOLEPSY},
  author={Seiji Nishino and Emmanuel Jean-Marie Mignot},
  journal={Progress in Neurobiology},
  year={1997},
  volume={52},
  pages={27-78}
}

Narcolepsy: Neuropharmacological Aspects

TLDR
Clinical and pharmacological aspects of narcolepsy as well as future directions are discussed.

Clinical and neurobiological aspects of narcolepsy.

Challenges in the development of therapeutics for narcolepsy

The pathogenesis of narcolepsy, current treatments and prospective therapeutic targets

TLDR
Development of synthetic hypocretin receptor agonists is the first and most urgent step for the improved treatment of Type 1 narcolepsy and will likely lead to developments of cell transplantation and gene therapies.

Sleep, sleep disorders and hypocretin (orexin).

  • E. Mignot
  • Biology, Psychology
    Sleep medicine
  • 2004

Overview of Management of Narcolepsy

TLDR
Clinical symptoms of narcolepsy are described, and the state-of-the-art knowledge about both pharmacological and non-pharmacological treatments ofNarcoleptic patients is reviewed.

Narcolepsy: new understanding of irresistible sleep.

TLDR
The current understanding of the diagnosis and treatment of narcolepsy is reviewed and the possible implications of the hypocretin discovery are discussed.

Clinical aspects and pathophysiology of narcolepsy

...

References

SHOWING 1-10 OF 323 REFERENCES

Neuropharmacology and neurochemistry of canine narcolepsy.

TLDR
It is demonstrated that cholinoceptive sites in the pontine reticular formation, as well as in the basal forebrain, are involved in the regulation of cataplexy, suggesting that a widespread hyperactivity of cholinergic systems within the central nervous system together with a hypoactivity of catecholaminergic systems underlie the pathophysiology of narcolepsy.

Dopamine D2 mechanisms in canine narcolepsy

  • S. NishinoJ. Arrigoni E. Mignot
  • Psychology, Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1991
TLDR
Using a canine model of the disease, it is found that central D2 antagonists suppressed cataplexy, a form of REM-sleep atonia occurring in narcolepsy, whereas this symptom was aggravated by D2 agonists, suggesting that the effect of D2 compounds on catapLexy is mediated secondarily via the noradrenergic systems.

Narcolepsy and cataplexy. Clinical features, treatment and cerebrospinal fluid findings.

TLDR
Clinical, EEG, and biochemical features of 20 patients with narcolepsy and one patient with the Kleine-Levin syndrome are described and some aspect of this may therefore be abnormal in patients with theNarcoleptic syndrome.

Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: implication for the pathophysiology of canine narcolepsy

  • S. NishinoM. Tafti E. Mignot
  • Biology, Psychology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1995
TLDR
Results suggest that a cholinoceptive site in the BF is critically implicated in triggering muscle atonia and cataplexy, and it appears that a widespread hypersensitivity to cholinergic stimulation may be central to the pathophysiology of canine narcolepsy.

Role of central alpha-1 adrenoceptors in canine narcolepsy.

TLDR
It is shown that the beneficial effects of classical treatments of human narcolepsy are antagonized by prazosin, suggesting that these drugs are active through an indirect alpha-1 stimulation (via an increase of norepinephrine in the synaptic cleft).

Narcolepsy-cataplexy in a female dog.

The nature of the narcoleptic sleep attack

TLDR
For many years, narcolepsy has been regarded as a sleep abnormality and it is assumed that knowledge pertaining to normal sleep mechanisms will aid in understanding the pathophysiology of the illness.

Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla.

TLDR
The data demonstrate that cataplexy is a distinct behavioral state, differing from other sleep and waking states in its pattern of brainstem neuronal activity.

Physiology of REM sleep, cataplexy, and sleep paralysis.

TLDR
The main neural structures generating muscle atonia and other phenomena characteristic of REM sleep are present in dorsolateral portions of the pons in the brainstem, and this last monoaminergic neuronal population probably has a gating or inhibiting effect upon the cholinergic and cholinoceptive neuronal populations related to the generation of generalized Muscle atonia in REM sleep.
...