PHARMACOKINETICS OF DEXTROMORAMIDE IN SURGICAL PATIENTS

@article{Pagani1989PHARMACOKINETICSOD,
  title={PHARMACOKINETICS OF DEXTROMORAMIDE IN SURGICAL PATIENTS},
  author={I. Pagani and Nicoletta Barzaghi and Francesca Crema and Emilio Perucca and Dominique Ego and Vincenzo Rovei},
  journal={Fundamental \& Clinical Pharmacology},
  year={1989},
  volume={3}
}
Summary— The pharmacokinetics of the narcotic analgesic dextromoramide was investigated by means of a specific GC‐MS method in 9 patients who were given a single oral dose of the drug (7.5 mg) together with an anticholinergic before undergoing minor orthopedic surgery. Dextromoramide was rapidly absorbed from the gastrointestinal tract, with peak plasma levels between 68 and 177 μ/L usually achieved within 0.5‐4.0 h after dosing. In 5 patients, the decline of plasma concentrations after the… 
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