Corpus ID: 30352257


  author={S. Debnath and P. Himabindhu and M. Niranjanbabu and I. Kureshi and G. Vanitha},
The complex process of aging is characterized by progressive loss in the functional capacities of organs, a reduction in mechanisms of homeostasis, and altered response to receptor stimulation. Medication therapy is among the most widely used and highly valued interventions for acute and chronic diseases of older adults, yet the use of drug therapy in the geriatric patient is one of the most difficult aspects of patient care. Alteration of the pharmacokinetics of these drugs in the elderly may… Expand


Altered pharmacokinetics in the elderly.
  • G. Yuen
  • Medicine
  • Clinics in geriatric medicine
  • 1990
Recognition of the relationship between physiologic changes and drug pharmacokinetics is important to better prescribe the correct dose in the elderly population. Expand
When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly
The age-related changes in the functions and composition of the human body require adjustments of drug selection and dosage for old individuals. Drug excretion via the kidneys declines with age, theExpand
Principles of drug therapy for the elderly patient.
The underlying reasons why the elderly population is at risk of adverse drug reactions are reviewed and the principles of drug-drug interaction, metabolism, and distribution are summarized to help elderly patients receive proper pharmacological treatment. Expand
The aging process.
The functional decline of the aging heart and the underlying mechanisms of that decline; quantitative and qualitative changes in the immune system; and normal aging of the human brain contrasted to the brain changes seen in Alzheimer disease are discussed. Expand
Longitudinal Studies on the Rate of Decline in Renal Function with Age
Serial creatinine clearances were obtained for 446 normal volunteers in the Baltimore Longitudinal Study of Aging followed between 1958 and 1981 and there was a small group of patients who showed a statistically significant increase (P < 0.05) in Creatinine clearance with age. Expand
The association of age with gastric emptying.
The results suggest that ageing does not impair this rate-limiting step in drug absorption, and gastric emptying in fit elderly and fit young volunteers is safe. Expand
Effects of Age and Aerobic Capacit on Arterial Stiffness in Healthy Adults
Interventions to improve aerobic capacity may mitigate the stiffening of the arterial tree that accompanies normative aging, as shown in the example of endurance trained older men relative to their less active age peers. Expand
The action of aging upon coronary intima and renal microvasculature in USA and Andes populations
The data reported here reveal the correlation of arteriolar hyalinization with fibroplasia and atheroma to persist in comparisons across geographically diverse populations, and suggests that aging of coronary intima, in so far as it bears upon preparation for atheromas, may vary in rate between populations. Expand
Coupled systolic-ventricular and vascular stiffening with age: implications for pressure regulation and cardiac reserve in the elderly.
Combined stiffening with age is matched by ventricular systolic stiffening even without hypertrophy and could further enhance pressure lability with diuretics and postural shifts in the elderly. Expand