PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.

@article{Hibi1999PGP95AA,
  title={PGP9.5 as a candidate tumor marker for non-small-cell lung cancer.},
  author={Kenji Hibi and William H Westra and M Borges and Simon L. Goodman and David Sidransky and Jin Jen},
  journal={The American journal of pathology},
  year={1999},
  volume={155 3},
  pages={
          711-5
        }
}
  • Kenji Hibi, William H Westra, +3 authors Jin Jen
  • Published in
    The American journal of…
    1999
  • Biology, Medicine
  • PGP9.5 is a neurospecific peptide that functions to remove ubiquitin from ubiquitinated proteins and prevents them from targeted degradation by proteasomes. Using the serial analysis of gene expression method (SAGE), we observed that the PGP9.5 transcript was highly expressed in primary lung cancers and lung cancer cell lines but was not detectable in the normal lung. Here we examined the expression of PGP9.5 protein in normal lung epithelium, lung tumor cell lines, and 98 resected primary non… CONTINUE READING

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