PGE2 production in oral cancer cell lines is COX-2-dependent.

  title={PGE2 production in oral cancer cell lines is COX-2-dependent.},
  author={Camilla Husvik and Cindy Khuu and Magne Bryne and Trond Sundby Halstensen},
  journal={Journal of dental research},
  volume={88 2},
It has been suggested that epithelial cyclooxygenase-2 (COX-2) promotes oral carcinogenesis and carcinoma malignancy through increased prostaglandin E(2) (PGE(2)) production. Although oral squamous cell carcinomas (OSCC) often express COX-2, they may also produce PGE(2) in a COX-1-dependent manner. We used 6 isolated cell lines to investigate which COX isoforms OSCC may use for PGE(2) production. COX-1 and -2 expression patterns divided the 6 OSCC cell lines into 3 distinct groups: both COX… CONTINUE READING
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