PGE2 increases substance P release from renal pelvic sensory nerves via activation of N-type calcium channels.

@article{Kopp1999PGE2IS,
  title={PGE2 increases substance P release from renal pelvic sensory nerves via activation of N-type calcium channels.},
  author={Ulla C Kopp and Michael Z Cicha},
  journal={The American journal of physiology},
  year={1999},
  volume={276 5 Pt 2},
  pages={R1241-8}
}
Activation of renal pelvic sensory nerves by increased pelvic pressure results in a renal pelvic release of substance P that is dependent on intact prostaglandin synthesis. An isolated renal pelvic wall preparation was used to examine whether PGE2 increases the release of substance P from renal pelvic sensory nerves and by what mechanisms. The validity of the model was tested by examining whether 50 mM KCl increased substance P release from the pelvic wall. Fifty millimolar KCl produced an… CONTINUE READING
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