PGE(2) sensitizes cultured pulmonary vagal sensory neurons to chemical and electrical stimuli.

@article{Kwong2002PGE2SC,
  title={PGE(2) sensitizes cultured pulmonary vagal sensory neurons to chemical and electrical stimuli.},
  author={Kevin Kwong and L V Lee},
  journal={Journal of applied physiology},
  year={2002},
  volume={93 4},
  pages={1419-28}
}
Mediators of inflammation, such as PGE(2), are known to sensitize the airways to inhaled irritants and circulating autacoids. Evidence from in vivo studies has shown the involvement of vagal pulmonary C-fiber afferents in the PGE(2)-elicited airway hypersensitivity. However, whether PGE(2) acts directly on these sensory nerves is unclear. The present study aimed to investigate whether PGE(2) has direct potentiating effects on nodose and jugular pulmonary C neurons cultured from adult Sprague… CONTINUE READING

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References

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Showing 1-10 of 41 references

Ionic Channels of Excitable Membranes (3rd ed.)

B. Hille
2001
View 3 Excerpts
Highly Influenced

Prostaglandin E2 potentiates capsaicin-induced calcium influx in cultured rat vagal sensory neurons (Abstract)

Q Gu, K Kwong, LY. Lee
Soc Neurosci Abstr • 2001
View 2 Excerpts

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