PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells.

@article{Obermajer2012PGE2drivenIA,
  title={PGE(2)-driven induction and maintenance of cancer-associated myeloid-derived suppressor cells.},
  author={Nata{\vs}a Obermajer and Jeffrey L. Wong and Robert Edwards and Kunle O Odunsi and Kirsten B Moysich and Pawel Kalinski},
  journal={Immunological investigations},
  year={2012},
  volume={41 6-7},
  pages={635-57}
}
Myeloid-derived suppressor cells (MDSCs) are critical mediators of tumor-associated immune suppression, with their numbers and activity strongly increased in most human cancers and animal models. MDSCs suppress anti-tumor immunity through multiple mechanisms, including the manipulation of arginine and tryptophan metabolism by such factors as arginase (Arg), inducible nitric oxide synthase (iNOS/NOS2), and indoleamine-2,3-dioxygenase (IDO). Prostaglandin E(2) (PGE(2)), a mediator of chronic… CONTINUE READING
40 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 40 extracted citations

Similar Papers

Loading similar papers…