PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.

@article{Bhalla2011PGC1PT,
  title={PGC1α promotes tumor growth by inducing gene expression programs supporting lipogenesis.},
  author={Kavita Bhalla and Bor Jang Hwang and Ruby E. Dewi and Lihui Ou and William Twaddel and Hong-Bin Fang and Scott B Vafai and Francesca Vazquez and Pere B. Puigserver and L{\'a}szl{\'o} G. Boros and Geoffrey D. Girnun},
  journal={Cancer research},
  year={2011},
  volume={71 21},
  pages={6888-98}
}
Despite the role of aerobic glycolysis in cancer, recent studies highlight the importance of the mitochondria and biosynthetic pathways as well. PPARγ coactivator 1α (PGC1α) is a key transcriptional regulator of several metabolic pathways including oxidative metabolism and lipogenesis. Initial studies suggested that PGC1α expression is reduced in tumors compared with adjacent normal tissue. Paradoxically, other studies show that PGC1α is associated with cancer cell proliferation. Therefore, the… CONTINUE READING