PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis.

@article{Sonoda2007PGC1betaCM,
  title={PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis.},
  author={Junichiro Sonoda and Isaac R. Mehl and Ling-Wa Chong and Russell R. Nofsinger and Ronald M Evans},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 12},
  pages={
          5223-8
        }
}
The transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1beta (PGC-1beta) is believed to control mitochondrial oxidative energy metabolism by activating specific target transcription factors including estrogen-related receptors and nuclear respiratory factor 1, yet its physiological role is not yet clearly understood. To define its function in vivo, we generated and characterized mice lacking the functional PGC-1beta protein [PGC-1beta knockout (KO) mice… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 125 CITATIONS, ESTIMATED 51% COVERAGE

Coactivators in PPAR-Regulated Gene Expression

  • PPAR research
  • 2010
VIEW 5 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Molecular Control of Cardiac Fetal/Neonatal Remodeling

VIEW 5 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

PGC1beta mediates PPARgamma activation of osteoclastogenesis and rosiglitazone-induced bone loss.

  • Cell metabolism
  • 2010
VIEW 6 EXCERPTS
CITES METHODS & BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 10 Highly Influenced Citations

  • Averaged 7 Citations per year from 2017 through 2019