PGC-1b Down-Regulation Is Associated With Reduced ERRa Activity and MCAD Expression in Skeletal Muscle of Senescence-Accelerated Mice

Abstract

Mitochondrial dysfunction is involved in the development of aging. Here, we examined the effect of aging on the skeletal muscle expression of two isoforms of the transcriptional peroxisome proliferator-activated receptor c (PPARc) coactivator-1 (PGC-1) in an experimental murine model of accelerated aging, the senescence-accelerated mouse (SAM). The… (More)

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