PGC-1alpha Down-Regulation Affects the Antioxidant Response in Friedreich's Ataxia

@inproceedings{Marmolino2010PGC1alphaDA,
  title={PGC-1alpha Down-Regulation Affects the Antioxidant Response in Friedreich's Ataxia},
  author={Daniele Marmolino and Mario Manto and Fabio Acquaviva and Paola Vergara and Ajay Ravella and Antonella Monticelli and Massimo Pandolfo},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Cells from individuals with Friedreich's ataxia (FRDA) show reduced activities of antioxidant enzymes and cannot up-regulate their expression when exposed to oxidative stress. This blunted antioxidant response may play a central role in the pathogenesis. We previously reported that Peroxisome Proliferator Activated Receptor Gamma (PPARgamma) Coactivator 1-alpha (PGC-1alpha), a transcriptional master regulator of mitochondrial biogenesis and antioxidant responses, is down-regulated in… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 81 references

Similar Papers

Loading similar papers…