PGC-1alpha, a new therapeutic target in Huntington's disease?


The coactivator PGC-1alpha is a key regulator of mitochondrial biogenesis and respiration, mediating expression of several transcription factors required for these programs. Three new studies reveal that PGC-1alpha expression is downregulated in patients with Huntington's disease (HD) and in several animal models of this neurodegenerative disorder… (More)


Cite this paper

@article{McGill2006PGC1alphaAN, title={PGC-1alpha, a new therapeutic target in Huntington's disease?}, author={Jetta K. McGill and M. Flint Beal}, journal={Cell}, year={2006}, volume={127 3}, pages={465-8} }