PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.

@article{Finck2006PGC1CI,
  title={PGC-1 coactivators: inducible regulators of energy metabolism in health and disease.},
  author={B. Finck and D. Kelly},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 3},
  pages={
          615-22
        }
}
  • B. Finck, D. Kelly
  • Published 2006
  • Biology, Medicine
  • The Journal of clinical investigation
Members of the PPARgamma coactivator-1 (PGC-1) family of transcriptional coactivators serve as inducible coregulators of nuclear receptors in the control of cellular energy metabolic pathways. This Review focuses on the biologic and physiologic functions of the PGC-1 coactivators, with particular emphasis on striated muscle, liver, and other organ systems relevant to common diseases such as diabetes and heart failure. 
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