PGC-1β in the Regulation of Hepatic Glucose and Energy Metabolism*

@article{Lin2003PGC1IT,
  title={PGC-1$\beta$ in the Regulation of Hepatic Glucose and Energy Metabolism*},
  author={Jiandie D. Lin and Paul T. Tarr and Ruojing Yang and James Rhee and Pere Puigserver and Christopher B. Newgard and Bruce M Spiegelman},
  journal={Journal of Biological Chemistry},
  year={2003},
  volume={278},
  pages={30843 - 30848}
}
Peroxisome proliferator-activated receptor γ coactivator-1α (PGC-1α) is a transcriptional coactivator that regulates multiple aspects of cellular energy metabolism, including mitochondrial biogenesis, hepatic gluconeogenesis, and β-oxidation of fatty acids. PGC-1α mRNA levels are increased in both type-1 and type-2 diabetes and may contribute to elevated hepatic glucose production in diabetic states. We have recently described PGC-1β, a novel transcriptional coactivator that is a homolog of PGC… Expand
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