PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

@article{Mootha2003PGC1responsiveGI,
  title={PGC-1α-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes},
  author={V. Mootha and C. Lindgren and K. Eriksson and A. Subramanian and S. Sihag and J. Leh{\'a}r and P. Puigserver and E. Carlsson and M. Ridderstr{\aa}le and E. Laurila and N. Houstis and M. Daly and N. Patterson and J. Mesirov and T. Golub and P. Tamayo and B. Spiegelman and E. Lander and J. Hirschhorn and D. Altshuler and L. Groop},
  journal={Nature Genetics},
  year={2003},
  volume={34},
  pages={267-273}
}
DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately… Expand
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