PGC-1α and exercise in the control of body weight

@article{Summermatter2012PGC1AE,
  title={PGC-1$\alpha$ and exercise in the control of body weight},
  author={Serge Summermatter and Christoph Handschin},
  journal={International Journal of Obesity},
  year={2012},
  volume={36},
  pages={1428-1435}
}
The increasing prevalence of obesity and its comorbidities represents a major threat to human health globally. Pharmacological treatments exist to achieve weight loss, but the subsequent weight maintenance is prone to fail in the long run. Accordingly, efficient new strategies to persistently control body weight need to be elaborated. Exercise and dietary interventions constitute classical approaches to reduce and maintain body weight, yet people suffering from metabolic diseases are often… Expand
PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner
TLDR
It is shown that elevated PGC-1α in combination with exercise preferentially improves glucose homeostasis, increases Krebs cycle activity, and reduces the levels of acylcarnitines and sphingosine, and patterns of lipid partitioning are altered in favor of enhanced insulin sensitivity in response to combined P GC-1 α and exercise. Expand
Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.
TLDR
Interestingly, the combination of age and loss of muscle Pgc-1α expression impaired glucose tolerance and led to increased fat mass, insulin resistance, and inflammatory markers in white adipose and liver tissues. Expand
New insights in the regulation of skeletal muscle PGC-1α by exercise and metabolic diseases
TLDR
Better knowledge about the regulation of PGC-1α by exercise would significantly help to design effective treatments for skeletal muscle energy metabolism diseases, including insulin resistant and type 2 diabetic patients. Expand
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise.
TLDR
The most recent developments in the study of muscle as an endocrine organ are summarized and the potential impact on the understanding of exercise and sedentary physiology, respectively are speculated. Expand
Skeletal muscle and beyond: the role of exercise as a mediator of systemic mitochondrial biogenesis.
TLDR
The purpose of this review is to highlight the effects of exercise, and the underlying mechanisms therein, on the induction of mitochondrial biogenesis in skeletal muscle, adipose tissue, liver, brain, and kidney. Expand
Recent data on obesity research: β-aminoisobutyric acid.
TLDR
The world eagerly expects to see how the BAIBA will compare with other recently reported agents to fight the overweight, and may be at the threshold of new and effective management of obesity. Expand
Caloric restriction and exercise "mimetics'': Ready for prime time?
TLDR
Resveratrol and other exercise- and caloric restriction "mimetics" are discussed with a special focus on feasibility, chances and limitations of using such compounds in patients as well as in healthy individuals. Expand
Dynamics of Fat Mass in DUhTP Mice Selected for Running Performance – Fat Mobilization in a Walk
TLDR
The findings indicate that the mitochondrial mass is highly active in DUhTP mice and responsive even to mild physical activity, and voluntary activity was sufficient to reduce excess body fat almost completely. Expand
Paternal exercise protects against liver steatosis in the male offspring of mice submitted to high fat diet.
TLDR
Findings suggest that paternal exercise training can improve the metabolic profile in the liver of the progeny, thereby ameliorating the effects of obesity. Expand
Effect of novel dietary supplement on metabolism in vitro and in vivo
TLDR
RF appears to increase metabolism immediately following ingestion, although it is unclear if RF provides benefits beyond those provided by caffeine alone, and additional research is needed to examine safety and efficacy for human weight loss. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 117 REFERENCES
Adaptive thermogenesis in humans
TLDR
The multiple systems regulating energy stores and opposing the maintenance of a reduced body weight illustrate that body energy stores in general and obesity in particular are actively ‘defended’ by interlocking bioenergetic and neurobiological physiologies. Expand
Up-regulation of PPARγ coactivator-1α as a strategy for preventing and reversing insulin resistance and obesity
TLDR
Current studies indicate that decreased expression of PPARγ coactivator-1 α (PGC-1α), a “master switch” which induces mitochondrial biogenesis by supporting the transcriptional activity of the nuclear respiratory factors, may largely account for the diminished oxidative capacity of subjects prone to insulin resistance. Expand
Up-regulation of PPARgamma coactivator-1alpha as a strategy for preventing and reversing insulin resistance and obesity.
TLDR
Recent studies indicate that decreased expression of PPARgamma coactivator-1 alpha (PGC-1alpha), a "master switch" which induces mitochondrial biogenesis by supporting the transcriptional activity of the nuclear respiratory factors, may largely account for the diminished oxidative capacity of subjects prone to insulin resistance. Expand
PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.
TLDR
There is substantial evidence that the p38gamma MAPK-PGC-1alpha regulatory axis is critical for exercise-induced metabolic adaptations in skeletal muscle, and strategies that upregulate PGC-1 alpha, within physiological limits, have revealed its insulin-sensitizing effects. Expand
Muscles and their myokines
  • B. Pedersen
  • Medicine, Biology
  • Journal of Experimental Biology
  • 2011
TLDR
The discovery that contracting skeletal muscle secretes proteins sets a novel paradigm: skeletal muscle is an endocrine organ producing and releasing myokines, which work in a hormone-like fashion, exerting specific endocrine effects on other organs. Expand
Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism
TLDR
Examination of body composition, energy balance, and liver and muscle insulin sensitivity by hyperinsulinemic-euglycemic clamp studies and muscle energetics by using 31P magnetic resonance spectroscopy in transgenic mice found no effect of increased muscle PGC-1α expression on whole-body energy expenditure. Expand
Endurance Exercise Mimetics in Skeletal Muscle
TLDR
Recent advances in the understanding of the key components of this circuitry that govern aerobic transformation of the skeletal muscles are described, raising the possibility of synthetically mimicking exercise with pathway-specific drugs to improve aerobic capacity and, in turn, health. Expand
Physical activity in the treatment of obesity: beyond body weight reduction.
  • P. Janiszewski, R. Ross
  • Medicine
  • Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme
  • 2007
TLDR
The independent role of physical activity in the treatment of obesity in a broader context is evaluated, through its effects on abdominal obesity and liver and muscle fat, in addition to its established effects on body weight and (or) total fat mass. Expand
Muscle-specific expression of PPARgamma coactivator-1alpha improves exercise performance and increases peak oxygen uptake.
TLDR
It is demonstrated that upregulation of PGC-1alpha in muscle in vivo is sufficient to greatly improve exercise performance under various exercise paradigms as well as increase peak oxygen uptake. Expand
Obesity-related derangements in metabolic regulation.
TLDR
Recent findings in lipid-induced functional impairments in the major peripheral organs that control energy flux are reviewed, placing emphasis on adipose tissue, the liver, skeletal muscle, and the pancreas. Expand
...
1
2
3
4
5
...