PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons.

  title={PGC-1\{alpha\} and PGC-1\{beta\} regulate mitochondrial density in neurons.},
  author={Przemyslaw Wareski and Annika Vaarmann and Vinay Choubey and Dzhamilja Safiulina and Joanna Liiv and Malle Kuum and Allen Kaasik},
  journal={The Journal of biological chemistry},
  volume={284 32},
Recent studies indicate that regulation of cellular oxidative capacity through enhancing mitochondrial biogenesis may be beneficial for neuronal recovery and survival in human neurodegenerative disorders. The peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) has been shown to be a master regulator of mitochondrial biogenesis and cellular energy metabolism in muscle and liver. The aim of our study was to establish whether PGC-1alpha and PGC-1beta control… CONTINUE READING


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