PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins.

@article{Tashima2006PGAP2IE,
  title={PGAP2 is essential for correct processing and stable expression of GPI-anchored proteins.},
  author={Yuko Tashima and Ryo Taguchi and Chie Murata and Hisashi Ashida and Taroh Kinoshita and Yusuke Maeda},
  journal={Molecular biology of the cell},
  year={2006},
  volume={17 3},
  pages={
          1410-20
        }
}
Biosynthesis of glycosylphosphatidylinositol-anchored proteins (GPI-APs) in the ER has been extensively studied, whereas the molecular events during the transport of GPI-APs from the ER to the cell surface are poorly understood. Here, we established new mutant cell lines whose surface expressions of GPI-APs were greatly decreased despite normal biosynthesis of GPI-APs in the ER. We identified a gene responsible for this defect, designated PGAP2 (for Post-GPI-Attachment to Proteins 2), which… CONTINUE READING

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