PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.

  title={PGAM5-mediated programmed necrosis of hepatocytes drives acute liver injury.},
  author={Gui-Wei He and Claudia G{\"u}nther and Andreas Kremer and Veronika Thonn and Kerstin Amann and Christopher Poremba and Markus F Neurath and Stefan Wirtz and Christoph Becker},
  volume={66 4},
OBJECTIVES Autoimmune hepatitis (AIH) is a severe necroinflammatory liver disease associated with significant mortality. Although loss of hepatocytes is generally recognised as a key trigger of liver inflammation and liver failure, the regulation of hepatic cell death causing AIH remains poorly understood. The aim of this study was to identify molecular mechanisms that drive hepatocyte cell death in the pathogenesis of acute liver injury. DESIGN Acute liver injury was modelled in mice by… CONTINUE READING
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