PGAM 5 tethers a ternary complex containing Keap 1 and Nrf 2 to mitochondria

@inproceedings{Lo2008PGAM5T,
  title={PGAM 5 tethers a ternary complex containing Keap 1 and Nrf 2 to mitochondria},
  author={Shih-Ching Lo and Mark Hannink},
  year={2008}
}
Article Chronology: Received 20 October 2007 Revised version received 21 January 2008 Accepted 21 February 2008 Available online 5 March 2008 Eukaryote cells balance production of reactive oxygen species (ROS) with levels of anti-oxidant enzymeactivity tomaintaincellular redoxhomeostasis.Mitochondriaareamajor sourceofROS, while many anti-oxidant genes are regulated by the Nrf2 transcription factor. Keap1, a redoxregulated substrate adaptor for a cullin-based ubiquitin ligase, targets Nrf2 for… CONTINUE READING